Recently published reviews articles and some original electronic based data collected researched articles have shown that diabetes mellitus (DM) has increased the chance of prevalence of tuberculosis (TB) in adults especially in the under developed countries where there is already epidemics of the TB disease exist. These findings are still hypothesis and are not supported by logical findings. DM gave birth to TB or vice versa is a debate which needs some better research work to document this fact. This mini critical review article will emphasize on some pharmacological, physiological and clinical aspects of both the diseases to show the connection of both diseases.