Respiratory tract infections are the most common infections in the developing countries. Its mode of spread is also very fast as compared to any other infection. Therefore; we have aimed this study based on the administration of two different drugs, Ciprox (Ciprofloxacin) and Augmentin (amoxicillin/clavulanate potassium), for the treatment of upper respiratory tract infection. A 25 years old female came in the local hospital of Rawalpindi (Pakistan) with the chief complaints of high grade fever of 103°F for 3 days with rigors and chills, flu and productive cough for 3 days, body rash and red spots for 1 day. The first doctor prescribed her tablet Ciprox (ciprofloxacin) 750 mg BID (twice a day), tablet Avil (pheniramine) 250 mg TID (three times a day), Paracetamol 500 mg TID and advised her to take healthy diet. Doctor also prescribed her blood C.P (complete picture) test and dengue virus test. Patient’s health condition became worse and then they sought another medical practitioner. The second physician prescribed her tablet Augmentin (amoxicillin/clavulanate potassium) 625 mg BID, syrup Cosome E (ammonium chloride/diphenhydramine) 1 table-spoon TID, tablet Paracetamol 500 mg and tablet Neo-Intestopan (Attapulgite) 630 mg TID. He also prescribed her herbal tea (Joshanda), honey in luke-warm water, noodles with soup and Chicken soup. Patient recovered from second treatment. Augmentin is more effective in upper respiratory tract infection and Ciprofloxacin can only be used as a 2nd line therapy only when resistance or hypersensitivity occurs from 1st line therapy. Thus; irrational drug usage and specious prescription are serious challenging in Pakistan. The clinical services and pharmaceutical care can work to rationalize the pharmacotherapy. Thus; the qualified pharmacist needed to induct in existing health care to safe precious lives