The utilization of plants for the development of new drugs and alternate therapies is mainly due to the wide spread confidence that medicines obtained from plants are secure, economical, and quite effective when compared with synthetically prepared medicines based on cost, efficacy, unwanted and harmful effects. This global trend for the use of medicines derived from natural sources particularly from plants has created an emergent need for accurate, detailed, and thorough information about the usefulness, particular constituent’s properties, effectiveness, and safety of plant and its products of medicinal interest. Pomegranate (Punica granatum; Latin name) is a fruit having deciduous shrub or little trees of 5-8 meters height. Pomegranate has become of great interest for researchers for the development of lots of new drugs because of its different nutritional components and their miraculous properties as improving skin health, anti-inflammatory agent, obesity reducer, antioxidant, antiviral, antimicrobial, anticancer, antidiabetic, antidiarrheal, its effects on different enzymes, effect on cellular differentiation. Previous researches have indicated that metabolites of Pomegranate fruit extract ellagitannins are particularly localized in colon, prostate gland, and mice intestinal tissues and show their effects. The objective of this review is to study all the constituents of pomegranate fruit, its dietary importance and physical, chemical as well as toxicological properties of this fruit. Thorough analysis of all these properties strongly suggests a wide range use of Pomegranate for clinical applications.