The bacterium Salmonella typhus causes acute symptoms of typhoid following gastro intestinal complications. Thus, we have examined a 20 year-old boy, presented in District Head Quarter (DHQ) Hospital Sargodha, Pakistan suffering from high grade fever since last two weeks. He had typical signs of typhoid. The Salmonella typhus was confirmed by laboratory investigations- Widal test. He was then recommended Ciprofloxacin and Levofloxacin with other symptomatic medication. The cure rate and effectiveness of these antibiotics were outstanding. Thus, we can infer that, the treatment was correct and rational, because patient was absolutely recovered within a week.