Main delineative of the present study was to ascertain the effectiveness of cefuroxime prophylaxis in restraining the postoperative wound infection during scavenging inguinal hernia mesh after furbish up surgery and also to equate single day with multiple day antibiotic prophylaxis during hospital stay and for monetary appraise. 326 patients with inguinal hernia were investigated and divided into two groups with 171 patients in group A and 155 in group B. Group A was treated with three intravenous doses just half an hour before surgery followed by two more doses with 8 hours interval and oral therapy of 500 mg of cefuroxime divided into two doses. Group B received six intravenous doses and followed by same oral therapy as of group A. Total therapy was carried out uninterrupted for 4 days in both groups. The outcomes of study indicated that 4.7% and 6.45% of the patients of group A and B explicated surgical site infections respectively, while the hospital detention of group A and B was 2.15 and 3.27 days respectively. Overall, the cost effectiveness of group A was 33% more frugal than Group B. It is concluded that there was no significant differences in one day and two days prophylaxis with cefuroxime in patients with inguinal hernia mesh repair surgery relative to post-operative surgical site infection. The risk of post-operative wound infection could therefore be efficaciously be contended by one day t.i.d treatment, eventually had salutary consequences on the hospital stay and cost obligingness of patient.